Key points
- PCOS weight loss is possible, but it is often harder. Insulin resistance, a stronger appetite and a tendency to gain weight over the years are part of the condition. It is not a lack of willpower.
- A small loss can make a real difference. The International PCOS Guideline has described a loss of 5–10% of body weight as an achievable goal that brings clear health gains. Studies link it to more regular cycles and better blood sugar.
- There is no single best PCOS diet. The guideline finds no evidence that one diet type beats another. Healthy eating that you enjoy and can keep up is what counts.
- Move in a way that suits your body. Walking and other aerobic activity, plus strength exercises on two days a week, help insulin work better, even before the scale moves.
- Sleep, mood and eating patterns matter. Sleep apnoea, low mood, anxiety and disordered eating are more common with PCOS and are worth raising with your doctor.
- Medicines and supplements are a decision for you and your doctor. We focus on good food, suitable exercise and walking, and we explain neutrally what the evidence says.
What is PCOS, and how is it linked to weight?
Polycystic ovary syndrome (PCOS) is a common, lifelong hormonal condition that affects how the ovaries work and how the body handles insulin. The International PCOS Guideline estimates that it affects 10 to 13 out of every 100 women of reproductive age worldwide.
Despite the name, PCOS is not really about cysts. The small “cysts” seen on a scan are egg follicles that have stopped developing.
Experts have proposed a new name, polyendocrine metabolic ovary syndrome (PMOS), to show that the condition reaches well beyond the ovaries. The European Society of Gynaecology supports a gradual change, with both names used side by side for a long time.
PCOS is one of several reasons weight can affect women differently; our page on obesity in women covers the others.
How PCOS is diagnosed
In adults, doctors diagnose PCOS when at least two of these three features are present, after other causes have been ruled out:
- Irregular or absent ovulation, which usually shows up as irregular, infrequent or missing periods.
- Higher levels of androgens (hormones such as testosterone), seen in a blood test or as extra facial or body hair, acne or thinning scalp hair.
- Polycystic ovaries on an ultrasound scan, or, in adults only, a raised level of anti-Müllerian hormone (AMH) in the blood.
For teenagers, the rules are stricter: both irregular cycles and high androgens are needed. If you recognise these signs, ask your doctor for an assessment rather than guessing.
Why weight and PCOS so often go together
PCOS occurs in women of every size, including slim women. Still, higher weight is much more common with the condition. A large review of 35 studies found that women with PCOS were almost three times as likely to live with obesity as women without it, and more likely to carry extra weight around the waist.
The link works in both directions. Extra body fat tends to raise insulin and androgen levels, which can make PCOS features stronger.
At the same time, PCOS itself seems to push the body towards gaining weight. Understanding that loop is the first step to breaking it gently.
Why losing weight with PCOS can be harder
Losing weight with PCOS can be harder because the condition changes how your body handles insulin, hunger and weight over time. These are biological differences, not personal failings. Knowing them helps you set fair expectations and choose strategies that work with your body instead of against it.
Insulin resistance
Insulin is the hormone that moves sugar from your blood into your cells. With insulin resistance, the cells respond less well, so the body makes extra insulin to compensate. In PCOS, high insulin also nudges the ovaries to make more androgens, which can disturb ovulation.
The guideline calls insulin resistance a key feature of PCOS. In a careful laboratory study using the most accurate test available, insulin resistance was found in 75% of slim women with PCOS and in 95% of women with PCOS and higher weight. It was more common than in women of the same weight without PCOS.
The same study showed that extra weight worsened insulin resistance more steeply in women with PCOS. That is why even a modest loss, and regular movement, can have a bigger effect on symptoms than you might expect.
You may wonder whether you should ask for an insulin test. The guideline advises against routine insulin blood tests, because the tests available in everyday care are not reliable enough to guide treatment. Your doctor will instead check blood sugar and cholesterol.
A stronger appetite after meals
Many women with PCOS say they never feel properly full. Research supports this experience. In one trial, women with PCOS felt less satisfied and more hungry after a test meal than women without PCOS, and their hunger hormone ghrelin responded less to eating.
The study was small, so it is not the final word. But it does suggest that “just eat less” ignores a real biological pull. Meals that are rich in protein, fibre and vegetables, eaten at regular times, give you a better chance against that pull.
A tendency to gain weight over the years
In a large Australian study of young women, those reporting PCOS gained more weight over ten years than women without it, by about 2.6 kg on average. The guideline concludes that many women with PCOS have underlying mechanisms that drive greater weight gain over time, even though the exact causes are still unclear.
Interestingly, a review of 54 studies with more than 39,000 women found that women with PCOS did not eat more calories or carbohydrate than other women. They did tend to be less physically active. In other words, the extra weight is not simply explained by eating habits.
Genes, hormones and the body’s own weight regulation all play a part. Our page on genetics and biology explains why the body often defends a higher weight, with or without PCOS.
| Challenge | What research shows | What can help |
|---|---|---|
| Insulin resistance | Very common in PCOS, at any weight | Regular movement, strength exercises, fibre-rich meals, gradual weight loss |
| Strong hunger after meals | Women with PCOS felt less full after a test meal | Protein and vegetables at each meal, regular meal times, enough sleep |
| Weight creeping up | More weight gain over ten years than women without PCOS | Preventing further gain is already a win; aim for small, lasting habits |
| Low mood and stress | Depression and anxiety are more common in PCOS | Support from your doctor, talking therapy, activity you enjoy |
| Poor sleep | Sleep apnoea is more common in PCOS | Ask your doctor about snoring and daytime tiredness |
| Weight stigma | Many women with PCOS meet it in healthcare | Respectful care, the right to choose how weight is discussed |
What losing 5–10% of your weight can do for PCOS
For women with PCOS and higher weight, losing 5–10% of body weight can bring clear improvements in cycles, fertility and metabolic health. The first edition of the International PCOS Guideline called this an achievable goal that brings significant clinical improvements, and counted it as successful weight loss within about six months.
The latest edition, led by Professor Helena Teede and colleagues, again states that weight management in women with higher weight can bring significant clinical improvements. It also stresses a lifelong focus on preventing further weight gain, which is a fair and useful goal in its own right.
For a woman weighing 100 kg, 5–10% means 5 to 10 kg. That is a long way from a “perfect” weight, and that is the point. You do not need to reach a particular BMI to feel and measure the benefits.
| Area | What studies have found |
|---|---|
| Periods and ovulation | More frequent, more regular periods; ovulation returning in some women |
| Fertility | Some women conceived after losing more than 5% of their weight |
| Hormones | Lower free androgen levels; more of the protein that binds testosterone |
| Blood sugar | Better insulin sensitivity and lower fasting insulin |
| Waist and heart health | Smaller waist and a better cholesterol profile |
| Hair and skin | Excess hair improved in some women, but evidence here is weaker |
What the studies show
A recent review of 29 randomised trial comparisons found that weight loss treatments, including both lifestyle programmes and medicines, improved insulin resistance, lowered the free androgen index and increased how often women had a period. The reviewers found no clear improvement in excess hair or quality of life, possibly because the studies were too small to show it.
A small, older study followed 24 women with PCOS through six to seven months of dietary treatment. Among the women who lost more than 5% of their weight and had cycle problems, 9 out of 11 either conceived or had more regular periods. Among those who lost less, only 1 out of 8 saw such an improvement. There was no comparison group, so this is a signal rather than proof.
A Cochrane review of lifestyle programmes in PCOS reached a similar but more cautious conclusion. Lifestyle change lowered weight and androgen levels, but the evidence was of low quality and most studies were small.
Benefits even if the scale barely moves
The guideline is clear that a healthy lifestyle brings benefits even without weight loss. Exercise can improve fitness, insulin resistance and waist size while your weight stays almost the same. Muscle gained from strength training can also hide fat loss on the scale.
So measure more than weight. Track your waist, your cycles, your energy, your step count and your blood results. If progress stalls, our page on what to do when you are not losing weight helps you find the reason.
PCOS diet: which eating pattern works best?
No single PCOS diet has been proven to work better than the others. After reviewing the evidence, the International PCOS Guideline found no support for any one diet composition over another, whether for weight, hormones, fertility, metabolism or mood.
Instead, the guideline recommends healthy eating in line with general population advice, tailored to your preferences and goals. It also warns against unduly restrictive and nutritionally unbalanced diets. That means you can pick the style that fits your culture, budget and taste, and still do well.
If you want to lose weight, the guideline says a tailored energy deficit can be used, based on your own needs, weight and activity level. A dietitian can work out what that means for you. Our comparison of the best diet for weight loss shows how popular eating styles stack up.
Eating principles that suit PCOS
Talk to your doctor first before you change the way you eat, especially if you have diabetes or take medicines. Then these principles give your meals a solid base:
- Build each meal around vegetables and protein. Fish, eggs, beans, lentils, chicken, tofu or yoghurt help you feel full for longer.
- Choose fibre-rich carbohydrates. Oats, wholegrain bread, brown rice, potatoes with skin, beans and fruit release energy more slowly than white bread, sweets or sugary drinks.
- Eat at regular times. Three meals, with a planned snack if you need one, stop extreme hunger from building up.
- Drink water, tea or coffee without sugar. Sugary drinks raise blood sugar fast and do little for fullness.
- Use healthy fats in modest amounts. Olive oil, nuts and seeds fit in well; fried and fatty processed foods are best kept occasional.
- Leave room for food you love. Plans that ban favourite foods rarely last.
For ideas on what to put on your plate, see our list of foods for weight loss, which focuses on filling, protein-rich and high-fibre choices.
Common PCOS diet myths
“You must cut out all carbohydrates.” Low-carbohydrate eating can work for some people, but the guideline does not find it better than other healthy patterns. Wholegrains, beans and fruit bring fibre that supports blood sugar and fullness.
“Keto is the PCOS diet.” A review of 11 trials, several of them small, found that women with PCOS lost weight on a ketogenic diet compared with control groups. But the results varied widely, most studies were short, and keto has not been shown to beat other well-planned diets over the long term.
Keto is also very restrictive, which makes it hard to keep up. If you want to try it, check with your doctor first, especially if you take medicines for diabetes or blood pressure.
“Everyone with PCOS should go dairy-free or gluten-free.” There is no good evidence that all women with PCOS need to avoid dairy or gluten. Only cut out a food group if a doctor or dietitian has found a reason, such as coeliac disease.
“A high-protein diet changes PCOS hormones.” In one trial, a higher-protein diet and a standard diet led to similar effects on hunger hormones and fullness in women with PCOS. Protein helps you feel full, but the overall pattern matters more than one nutrient.
What about inositol and other supplements?
Inositol is a supplement that is widely sold for PCOS. The International PCOS Guideline concludes that it causes little harm and may improve some metabolic measures, but that its benefits for ovulation, excess hair and weight are limited. No specific type, dose or combination can currently be recommended because good-quality evidence is lacking.
The guideline also points out that supplements are not checked in the same way as medicines, so their quality and dose can vary. If you take inositol or any other supplement, or are thinking about it, ask your doctor, and always tell them what you take.
Exercise for PCOS: aerobic activity plus strength
The best exercise for PCOS is the one you can do regularly, and a mix of aerobic activity and strength training covers the most ground. The guideline finds no evidence that one type or intensity of exercise beats another for weight, hormones or fertility, so your preferences and your body come first.
Talk to your doctor first before you start, especially if you have joint pain, heart problems, high blood pressure or diabetes. Then start well within your comfort zone and build up slowly.
How much activity the guideline advises
For general health and to prevent weight gain, adults with PCOS are advised to aim for 150 to 300 minutes of moderate activity a week, such as brisk walking, or 75 to 150 minutes of vigorous activity. Muscle-strengthening exercises should be added on two days that are not back to back.
For modest weight loss and to avoid regaining weight, the guideline suggests a higher target: at least 250 minutes of moderate activity a week, or 150 minutes of vigorous activity, again with strength exercises twice a week. That is a goal to grow towards over months, not where you start.
Any movement counts. The guideline lists walking or cycling to the shops, housework, gardening and playing with children alongside planned exercise. Cutting down sitting time is useful in itself.
Aerobic activity and walking
Aerobic activity raises your heart rate and breathing. In a network analysis of 19 trials in women with PCOS, moderate-intensity aerobic exercise was the type that reduced BMI.
Walking is the easiest place to start: it is free, needs no equipment and can be built up step by step. Our walking guide shows how.
A review of exercise studies in PCOS found that more vigorous exercise gave the largest gains in fitness, insulin resistance and waist size. Vigorous does not have to mean running. Walking uphill, cycling a little faster or a brisk water workout can all raise the effort once you are ready.
If your knees, hips or back make walking hard, try low-impact cardio such as seated workouts, cycling or swimming. These protect your joints while still working your heart.
Strength training
Strength training builds muscle, and muscle is one of the main places where your body uses sugar from the blood. More muscle can help insulin work better and makes everyday tasks easier. You can start with body-weight moves such as sit-to-stands from a chair or wall push-ups.
Our guide to strength training for beginners explains how to start safely at home, including with sore knees.
| Level | Aerobic activity | Strength |
|---|---|---|
| Start | 10-minute walks or seated cardio on most days | One short chair-based session, twice a week |
| Build | 20–30 minutes of brisk walking on five days | 20-minute body-weight session, twice a week |
| Strong | 30–50 minutes on most days, some uphill or faster | 30-minute session with weights, twice a week |
Many women with PCOS feel self-conscious about exercising in public. The guideline names body image concerns and fear of failure as real barriers. Home workouts, an early-morning walk or a friend who joins you can make a big difference.
Sleep, mood and emotional eating with PCOS
Sleep problems, low mood and difficult eating patterns are more common in PCOS, and each of them can make weight loss harder. They deserve attention in their own right, not only as obstacles to losing weight.
Sleep and sleep apnoea
Obstructive sleep apnoea means your breathing repeatedly stops and starts during sleep. The guideline notes that women with PCOS have a much higher rate of sleep apnoea than women without PCOS, and that this holds at any BMI. It advises asking every woman with PCOS about the typical symptoms.
Poor sleep raises hunger and makes it harder to be active the next day. If you snore and wake up unrefreshed, or feel very sleepy or tired during the day, ask your doctor about a sleep assessment. Our page on sleep, stress and mental health has tips for better sleep.
Low mood and anxiety
Depression and anxiety are very common in PCOS, so common that the guideline advises screening all women with the condition. Symptoms such as excess hair, acne, fertility worries and weight concerns all weigh on mental health.
Low mood saps energy and motivation, which makes new habits hard to keep. Getting support for your mood is part of looking after your weight, not a distraction from it.
Emotional eating and disordered eating
Many people eat to cope with stress, sadness or boredom. Our page on emotional eating offers a practical toolkit to ease cravings without guilt.
Sometimes eating feels more out of control than that. A review that informed the guideline found that women with PCOS have higher odds of binge eating disorder and bulimia nervosa, at any weight. Strict dieting can make these problems worse.
If you often eat large amounts and feel you cannot stop, or you feel strong shame or distress after eating, please talk to your doctor before you start a weight loss plan. Binge eating disorder is treatable, and the right support comes first.
Weight stigma in PCOS care
Many women with PCOS experience weight stigma in healthcare, and the International PCOS Guideline formally recognises the harm it causes. Being told to “just lose weight”, without help or a proper look at other symptoms, is a common experience.
The guideline asks health professionals to be aware of their own weight bias and to care for every woman well, regardless of her size. In practice, it says professionals should:
- ask permission before discussing or measuring your weight, and explain why the number matters for your care;
- offer the option of being weighed without seeing the number;
- use respectful words such as “higher weight”;
- have equipment, such as blood pressure cuffs and examination tables, that fits people of all sizes;
- offer you a choice between care that aims for weight loss and care that focuses on healthy habits without a weight target.
Weight is only one marker of health. Your periods, skin, hair, mood, fertility, blood sugar and blood pressure all deserve attention, whatever you weigh.
If you have felt judged, you are not alone, and you have the right to ask for respectful care or a different professional. Our page on weight stigma in healthcare explains your options.
Medicines and PCOS: a decision for you and your doctor
Several medicines are used in PCOS care, and whether any of them is right for you is a decision for you and your doctor. We describe what the guideline says, neutrally, so you can have an informed conversation.
Metformin, a medicine also used for type 2 diabetes, is one option the guideline discusses for adults with PCOS and higher weight, mainly for its effects on insulin resistance, blood sugar and cholesterol. The guideline says women should be told that metformin and an active lifestyle programme have similar efficacy.
Stomach and bowel side effects are common, and long-term use can lower vitamin B12.
The contraceptive pill is often used to regulate periods and reduce excess hair. Other medicines are sometimes discussed for weight in PCOS, as in the general population. Each has benefits, side effects and costs, and availability differs by country.
Whether medication is right for you is something to discuss with your doctor. Obesity Foundation does not recommend or promote weight-loss medication; our focus is good food, appropriate exercise and walking.
Never start, stop or change a medicine on your own, and tell your doctor about any supplements you take.
What to ask your doctor about PCOS and weight
A good appointment covers your symptoms, your health risks and the support that fits your goals. Women with PCOS have a higher risk of type 2 diabetes at any age and weight, so the guideline advises checking blood sugar at diagnosis and then every one to three years. A cholesterol check and a blood pressure reading are also part of good care.
Questions you could bring:
- Has my blood sugar been checked, and when should it be checked again?
- What are my cholesterol and blood pressure, and do they need attention?
- Could my tiredness or snoring be a sign of sleep apnoea?
- My periods are very irregular: is anything needed to protect the lining of my womb?
- Can you refer me to a dietitian, a physiotherapist or an exercise specialist?
- What is a realistic weight goal for me, and how will we measure progress beyond the scale?
- My mood has been low: can we talk about support?
- I am planning a pregnancy: what should I do first?
Write your questions down and bring them with you. Our doctor visit checklist helps you prepare, so nothing important gets forgotten.
Losing weight with PCOS when you want a baby
PCOS is one of the most common causes of irregular ovulation, but the guideline reassures women that pregnancy can often be achieved, either naturally or with help. For women with higher weight, gradual weight loss before pregnancy can improve the chance of ovulating.
Because the risk of high blood sugar in pregnancy is raised, the guideline advises considering a glucose tolerance test for women with PCOS who are planning a pregnancy or seeking fertility treatment. Pregnancy with PCOS is also considered higher risk, so early antenatal care is important.
Please do not put off fertility advice while you try to lose weight. A fertility specialist can weigh your age, your cycles and your health together.
Avoid crash diets before or during pregnancy: steady habits are safer for you and your baby. Our page on obesity and pregnancy covers preparation and care in more detail.
After the birth, our guide to postpartum weight loss explains when and how to start gently.
A 12-week PCOS weight loss plan
A good PCOS weight loss plan changes a few habits at a time and keeps them going. Talk to your doctor first before you start this plan, especially if you take medicines, have diabetes or joint problems, or are pregnant or trying to become pregnant. This is general guidance, not personal advice.
| Weeks | Food | Movement | Wellbeing |
|---|---|---|---|
| 1–2 | Three regular meals; add vegetables to two of them | Short daily walks; note your steps | Set a fixed bedtime; book a doctor’s check |
| 3–4 | Protein at every meal; swap sugary drinks for water | Add one strength session a week | Keep a short food-and-mood diary |
| 5–8 | Swap white bread and rice for wholegrains; plan snacks | Brisk walks on five days; two strength sessions | Review your diary; plan for hard moments |
| 9–12 | Cook a few batch meals; keep favourite foods in small portions | Lengthen or speed up some walks | Check waist, cycles and energy, not only weight |
Aim for a slow, steady pace of loss rather than a fast drop. Some weeks the scale will not move at all, and that is normal.
If you would like a structure for your meals, our free eating plan gives you regular, satisfying meals without banned foods. It works well alongside the steps above.
After 12 weeks, keep what worked and adjust what did not. Many women with PCOS find that keeping weight steady is hard work in itself, so give yourself credit for every habit you hold on to.
How Obesity Foundation helps you lose weight with PCOS
We help people with PCOS lose weight and feel better with good food, suitable exercise and walking. Everything we offer is free, without a subscription.
- A free eating plan: regular meals rich in protein, vegetables and fibre to keep hunger steady. Request your free eating plan.
- Free workout videos: 150 videos in three levels, from gentle chair-based Start sessions to Build and Strong. Get the free workout videos.
- A free video meeting (in English): talk with one of our volunteers about your plan, your progress and your questions for the doctor. Book a free video meeting.
- The free Obesity Foundation Club: your own account to log walks and workouts, track your goal and ask for help. Join the Club.
Our volunteers are not doctors, and a video meeting does not replace medical care. For diagnosis, tests, medicines and fertility questions, your own doctor is the right person.
PCOS can make weight loss slower, but it does not make it impossible. With realistic goals, food you enjoy, movement that suits your body and people on your side, small steps add up.
Frequently asked questions
Can you lose weight with PCOS?
Yes. Weight loss programmes work in women with PCOS much as they do in other people, although progress is often slower because of insulin resistance and a stronger appetite. Regular meals rich in protein and fibre, daily walking, strength exercises twice a week, enough sleep and ongoing support give you the best chance.
How much weight do I need to lose to help my PCOS?
Not as much as many women think. The International PCOS Guideline has described a loss of 5–10% of body weight as an achievable and successful goal, and in one small study most women with cycle problems who lost more than 5% had more regular periods or conceived. Healthy habits also bring benefits when your weight hardly changes.
Does losing weight cure PCOS?
No. PCOS is a lifelong condition, so weight loss does not make it disappear. For women with higher weight, though, losing some weight can ease symptoms such as irregular periods and high androgen levels and help insulin work better. Some women find their cycles become regular again.
What is a PCOS belly?
“PCOS belly” is a popular term for extra weight carried around the waist. Women with PCOS are more likely to store fat there, and that kind of fat is closely linked to insulin resistance. You cannot target belly fat alone, but regular activity, strength training and a balanced way of eating can reduce your waist size, sometimes before the scale shows much change.
What is the best exercise for PCOS?
The one you will keep doing. The International PCOS Guideline found no evidence that one type or intensity of exercise works better than another, so choose activities you enjoy. A good mix is regular walking or other aerobic activity plus strength exercises on two days a week, built up gradually.
Should I take inositol for PCOS weight loss?
The International PCOS Guideline concludes that inositol causes little harm and may improve some metabolic measures, but that its effects on weight, ovulation and excess hair are limited. No specific type or dose can be recommended because good evidence is lacking, and supplement quality varies. Ask your doctor before you take it.
Sources
- Teede HJ et al. – Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Human Reproduction (2023)
- Teede HJ et al. – Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Human Reproduction (2018)
- Castelo-Branco C et al. – European Society of Gynecology (ESG) position paper on the proposed terminology change from PCOS to PMOS. Gynecological Endocrinology (2026)
- Lim SS, Davies MJ, Norman RJ, Moran LJ – Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction Update (2012)
- Stepto NK et al. – Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp. Human Reproduction (2013)
- Moran LJ et al. – Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. Journal of Clinical Endocrinology & Metabolism (2004)
- Teede HJ et al. – Longitudinal weight gain in women identified with polycystic ovary syndrome: results of an observational study in young women. Obesity (2013)
- Kazemi M et al. – Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women. Human Reproduction Update (2022)
- Scragg J et al. – Effect of weight loss interventions on the symptomatic burden and biomarkers of polycystic ovary syndrome: a systematic review of randomized controlled trials. Annals of Internal Medicine (2024)
- Kiddy DS et al. – Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clinical Endocrinology (1992)
- Lim SS et al. – Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews (2019)
- Xing NN, Ren F, Yang H – Effects of ketogenic diet on weight loss parameters among obese or overweight patients with polycystic ovary syndrome: a systematic review and meta-analysis. Food & Nutrition Research (2024)
- Patten RK et al. – Exercise interventions in polycystic ovary syndrome: a systematic review and meta-analysis. Frontiers in Physiology (2020)
- Motaharinezhad F et al. – The effects of different exercises on weight loss and hormonal changes in women with polycystic ovarian syndrome: a network meta-analysis study. BMC Women’s Health (2024)
- Cooney LG et al. – Increased prevalence of binge eating disorder and bulimia nervosa in women with polycystic ovary syndrome: a systematic review and meta-analysis. Journal of Clinical Endocrinology & Metabolism (2024)
